To find out what we are currently doing then check out our most recent publications at PubMed
It is being increasingly realised that bacteria communicate and cooperate to perform a wide range of multicellular behaviours such as dispersal, foraging, biofilm formation, chemical warfare and quorum sensing. Microbiologists have made huge strides forward, using molecular approaches, in determining how certain behaviours function. Despite this, answers are still lacking to some basic questions, such as why do these behaviours evolve, are they social, and how are they maintained in natural populations?
We are interested in the evolution of microbial cooperative behaviors and signaling systems (quorum sensing) and the implications for the evolution of virulence and antibiotic resistance during infection. Our emphasis is on chronic infections such as those found in cystic fibrosis lungs, diabetic ulcers and non-healing wounds. The main organisms that we focus on are the antibiotic resistant superbugs Pseudomonas aeruginosa and Staphylococcus aureus.
We are also determining whether ancient medieval recipes can be used to treat infectious disease (ancientbiotics). We build recipes in the lab which are translated from ancient texts, and test them against antibiotic resistant bacteria. We previously reconstructed a 10th century recipe from 'Bald's Leechbook' and demonstrated that it has anti-Staphylococcal activity.
Main Findings (our work and collaboration with others)
Social evolution, quorum sensing, the evolution of virulence
Chronic infection and biofilms